2.4M XNAS Volume
XNAS 25 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Bethany J. Cavanagh | SVP, Finance and Treasurer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 18 Feb 2025 | 6,287 | 37,527 (0%) | 0% | 35 | 220,045 | Common Stock |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 9,492 | 0 | - | - | Stock Option (Right to Buy) | |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 14 Feb 2025 | 9,492 | 112,460 (0%) | 0% | 7.2 | 68,532 | Common Stock |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 14 Feb 2025 | 508 | 112,968 (0%) | 0% | 7.2 | 3,668 | Common Stock |
| Christine Bellon | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 14 Feb 2025 | 10,000 | 102,968 (0%) | 0% | 34 | 340,000 | Common Stock |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 508 | 10,410 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Christine Bellon | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Amy Simon | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Bethany J. Cavanagh | SVP, Finance and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 26.75 per share. | 30 Jan 2025 | 29,800 | 908,859 (1%) | 0% | 26.7 | 797,028 | Common Stock |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 155,000 | 155,000 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 27.28 per share. | 30 Jan 2025 | 200 | 908,659 (1%) | 0% | 27.3 | 5,456 | Common Stock |
| Christine Bellon | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 24.68 per share. | 02 Jan 2025 | 1,241 | 102,968 (0%) | 0% | 24.7 | 30,628 | Common Stock |
| Bethany J. Cavanagh | SVP, Finance and Treasurer | 02 Jan 2025 | 1,117 | 43,814 (0%) | 0% | 24.7 | 27,568 | Common Stock | |
| Emany Sravan K. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 80,000 | 80,000 (0%) | 0% | 0 | Common Stock | |
| K. Sravan Emany | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 160,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2024 | 53,500 | 6,505 | - | - | Stock Option (Right to Buy) | |
| Ciaramella Giuseppe | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 17 Dec 2024 | 53,500 | 162,650 (0%) | 0% | 0.7 | 35,845 | Common Stock |
| Chirfi Guindo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2024 | 39,086 | 39,086 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Sale of securities on an exchange or to another person at price $ 26.36 per share. | 06 Nov 2024 | 51,110 | 109,150 (0%) | 0% | 26.4 | 1,347,050 | Common Stock |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 1,457 | 0 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 12,979 | 0 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 27,318 | 0 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Sale of securities on an exchange or to another person at price $ 26.27 per share. | 14 Oct 2024 | 51,110 | 160,260 (0%) | 0% | 26.3 | 1,342,752 | Common Stock |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 14 Oct 2024 | 1,457 | 211,370 (0%) | 0% | 7.2 | 10,520 | Common Stock |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 14 Oct 2024 | 27,318 | 196,934 (0%) | 0% | 0.7 | 18,303 | Common Stock |
| Giuseppe Ciaramella | President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.22 per share. | 14 Oct 2024 | 12,979 | 209,913 (0%) | 0% | 4.2 | 54,771 | Common Stock |
| Christine Bellon | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 23.48 per share. | 01 Oct 2024 | 385 | 104,209 (0%) | 0% | 23.5 | 9,040 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 24.60 per share. | 30 Sep 2024 | 60,000 | 938,659 (1%) | 0% | 24.6 | 1,476,024 | Common Stock |
| Bethany J. Cavanagh | SVP, Finance and Treasurer | 30 Sep 2024 | 289 | 44,931 (0%) | 0% | 23.5 | 6,785 | Common Stock | |
| Bethany J. Cavanagh | SVP, Finance and Treasurer | 30 Sep 2024 | 2,500 | 45,220 (0%) | 0% | 0 | Common Stock | ||
| Bethany J. Cavanagh | SVP, Finance and Treasurer | 31 Aug 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | ||
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.76 per share. | 01 Jul 2024 | 502 | 69,553 (0%) | 0% | 23.8 | 11,928 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 22.95 per share. | 01 Jul 2024 | 748 | 68,805 (0%) | 0% | 23.0 | 17,167 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 24.50 per share. | 27 Jun 2024 | 60,000 | 998,343 (2%) | 0% | 24.5 | 1,470,156 | Common Stock |
| Graham K. Cooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 23,114 | 23,114 | - | - | Stock Option (Right to Buy) | |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 23,114 | 23,114 | - | - | Stock Option (Right to Buy) | |
| Mark C. Fishman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 23,114 | 23,114 | - | - | Stock Option (Right to Buy) | |
| Kathleen E. Walsh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 23,114 | 23,114 | - | - | Stock Option (Right to Buy) | |
| Christi Shaw | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 23,114 | 23,114 | - | - | Stock Option (Right to Buy) | |
| Carole Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 23,114 | 23,114 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2024 | 12,500 | 82,637 (0%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 53,965 | 53,965 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 32.13 per share. | 01 Apr 2024 | 18,102 | 1,058,343 (2%) | 0% | 32.1 | 581,617 | Common Stock |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 99,336 | 99,336 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Sale of securities on an exchange or to another person at price $ 32.12 per share. | 01 Apr 2024 | 4,534 | 169,616 (0%) | 0% | 32.1 | 145,632 | Common Stock |
| Giuseppe Ciaramella | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 12,979 | 12,979 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 27,318 | 27,318 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 32.12 per share. | 01 Apr 2024 | 5,446 | 70,137 (0%) | 0% | 32.1 | 174,926 | Common Stock |
| Christine Bellon | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 32.12 per share. | 01 Apr 2024 | 3,401 | 104,594 (0%) | 0% | 32.1 | 109,240 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 32.13 per share. | 01 Apr 2024 | 7,157 | 86,590 (0%) | 0% | 32.1 | 229,954 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.54 per share. | 01 Apr 2024 | 16,530 | 70,060 (0%) | 0% | 30.5 | 504,851 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2024 | 27,500 | 75,583 (0%) | 0% | 0 | Common Stock | |
| Christine Bellon | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2024 | 27,500 | 107,995 (0%) | 0% | 0 | Common Stock | |
| Amy Simon | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2024 | 27,500 | 93,747 (0%) | 0% | 0 | Common Stock | |
| Giuseppe Ciaramella | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2024 | 35,000 | 174,150 (0%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2024 | 77,500 | 1,076,445 (2%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 33.86 per share. | 28 Mar 2024 | 60,000 | 998,262 (2%) | 0% | 33.9 | 2,031,402 | Common Stock |
| Simon Amy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Evans John | Director, CEO | Sale of securities on an exchange or to another person at price $ 25.33 per share. | 31 Jan 2024 | 60,000 | 1,058,262 (2%) | 0% | 25.3 | 1,519,800 | Common Stock |
| Christine Bellon | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 155,000 | 155,000 | - | - | Stock Option (Right to Buy) | |
| Ciaramella Giuseppe | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Bellon Christine | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 26.42 per share. | 03 Jan 2024 | 1,907 | 80,495 (0%) | 0% | 26.4 | 50,383 | Common Stock |
| Shaw Christi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2023 | 39,046 | 39,046 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President and CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 21 Jul 2023 | 21,846 | 203,574 (0%) | 0% | 7.2 | 157,728 | Common Stock |
| Giuseppe Ciaramella | President and CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 21 Jul 2023 | 69,438 | 181,728 (0%) | 0% | 7.2 | 501,342 | Common Stock |
| Giuseppe Ciaramella | President and CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2023 | 1,206 | 19,002 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President and CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2023 | 21,846 | 1,457 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President and CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2023 | 69,438 | 20,208 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President and CSO | Sale of securities on an exchange or to another person at price $ 32.01 per share. | 21 Jul 2023 | 1,206 | 48,250 (0%) | 0% | 32.0 | 38,604 | Common Stock |
| Giuseppe Ciaramella | President and CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 21 Jul 2023 | 1,206 | 49,456 (0%) | 0% | 7.2 | 8,707 | Common Stock |
| Giuseppe Ciaramella | President and CSO | Sale of securities on an exchange or to another person at price $ 32.06 per share. | 21 Jul 2023 | 155,324 | 48,250 (0%) | 0% | 32.1 | 4,979,687 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.48 per share. | 10 Jul 2023 | 391 | 68,917 (0%) | 0% | 30.5 | 11,918 | Common Stock |
| Graham K. Cooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 16,532 | 16,532 | - | - | Stock Option (Right to Buy) | |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 16,532 | 16,532 | - | - | Stock Option (Right to Buy) | |
| Mark C. Fishman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 16,532 | 16,532 | - | - | Stock Option (Right to Buy) | |
| Kristina M. Burow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 16,532 | 16,532 | - | - | Stock Option (Right to Buy) | |
| Kathleen E. Walsh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 16,532 | 16,532 | - | - | Stock Option (Right to Buy) | |
| Carole Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 16,532 | 16,532 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 30.31 per share. | 03 Apr 2023 | 5,161 | 1,124,472 (2%) | 0% | 30.3 | 156,430 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 29.09 per share. | 03 Apr 2023 | 6,493 | 1,117,979 (2%) | 0% | 29.1 | 188,904 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 29.09 per share. | 03 Apr 2023 | 1,754 | 112,290 (0%) | 0% | 29.1 | 51,029 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 30.31 per share. | 03 Apr 2023 | 1,918 | 114,044 (0%) | 0% | 30.3 | 58,135 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.09 per share. | 03 Apr 2023 | 2,186 | 47,117 (0%) | 0% | 29.1 | 63,598 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.31 per share. | 03 Apr 2023 | 2,454 | 49,303 (0%) | 0% | 30.3 | 74,381 | Common Stock |
| Christine Bellon | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 30.31 per share. | 03 Apr 2023 | 931 | 83,951 (0%) | 0% | 30.3 | 28,219 | Common Stock |
| Christine Bellon | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 29.09 per share. | 03 Apr 2023 | 1,161 | 82,790 (0%) | 0% | 29.1 | 33,777 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.77 per share. | 03 Apr 2023 | 10,493 | 70,469 (0%) | 0% | 29.8 | 312,339 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.31 per share. | 03 Apr 2023 | 4,445 | 80,962 (0%) | 0% | 30.3 | 134,728 | Common Stock |
| Amy Simon | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.09 per share. | 03 Apr 2023 | 1,161 | 69,308 (0%) | 0% | 29.1 | 33,777 | Common Stock |
| Amy Simon | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 20,000 | 85,129 (0%) | 0% | 0 | Common Stock | |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 30 Mar 2023 | 6,272 | 64,713 (0%) | 0% | 7.2 | 45,284 | Common Stock |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 30 Mar 2023 | 2,669 | 67,382 (0%) | 0% | 7.2 | 19,270 | Common Stock |
| Christine Bellon | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Mar 2023 | 17,500 | 84,882 (0%) | 0% | 0 | Common Stock | |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2023 | 6,272 | 13,674 | - | - | Stock Option (Right to Buy) | |
| Christine Bellon | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2023 | 2,669 | 16,736 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 112,500 | 112,500 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | 31 Jan 2023 | 225 | 1,059,053 (2%) | 0% | 0 | Common Stock | ||
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 56,250 | 1,115,303 (2%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 31 Jan 2023 | 13,850 | 1,129,153 (2%) | 0% | 7.2 | 99,997 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2023 | 13,850 | 196,904 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 20,000 | 115,962 (0%) | 0% | 0 | Common Stock | |
| Terry-Ann Burrell | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 26 Jan 2023 | 1,102 | 32,379 (0%) | 0% | 13.7 | 15,075 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jan 2023 | 36,152 | 185,565 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jan 2023 | 1,102 | 221,717 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.16 per share. | 26 Jan 2023 | 1,102 | 31,277 (0%) | 0% | 45.2 | 49,763 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.08 per share. | 26 Jan 2023 | 36,152 | 31,277 (0%) | 0% | 45.1 | 1,629,747 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 26 Jan 2023 | 36,152 | 67,429 (0%) | 0% | 13.7 | 494,559 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 23 Jan 2023 | 14,810 | 31,277 (0%) | 0% | 45.0 | 666,657 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.02 per share. | 23 Jan 2023 | 5,426 | 31,277 (0%) | 0% | 45.0 | 244,290 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 23 Jan 2023 | 5,426 | 36,703 (0%) | 0% | 13.7 | 74,228 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2023 | 14,810 | 222,819 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2023 | 5,426 | 237,629 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 23 Jan 2023 | 14,810 | 46,087 (0%) | 0% | 13.7 | 202,601 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 18 Jan 2023 | 39,886 | 78,472 (0%) | 0% | 13.7 | 545,640 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.14 per share. | 18 Jan 2023 | 47,195 | 31,277 (0%) | 0% | 45.1 | 2,130,382 | Common Stock |
| Terry-Ann Burrell | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2023 | 39,886 | 243,055 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 03 Jan 2023 | 9,106 | 105,068 (0%) | 0% | 0.7 | 6,101 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 40,297 | 150,905 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 4,326 | 0 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 9,106 | 0 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 39.94 per share. | 03 Jan 2023 | 600 | 95,962 (0%) | 0% | 39.9 | 23,964 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 39.07 per share. | 03 Jan 2023 | 1,900 | 96,562 (0%) | 0% | 39.1 | 74,233 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 03 Jan 2023 | 40,297 | 149,691 (0%) | 0% | 0.7 | 26,999 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.22 per share. | 03 Jan 2023 | 4,326 | 109,394 (0%) | 0% | 4.2 | 18,256 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 37.14 per share. | 03 Jan 2023 | 37,525 | 112,166 (0%) | 0% | 37.1 | 1,393,679 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 37.99 per share. | 03 Jan 2023 | 13,704 | 98,462 (0%) | 0% | 38.0 | 520,615 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 30 Dec 2022 | 4,500 | 95,962 (0%) | 0% | 0.7 | 3,015 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Dec 2022 | 4,500 | 191,202 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2022 | 18,211 | 9,106 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 46.19 per share. | 31 Oct 2022 | 4,569 | 113,423 (0%) | 0% | 46.2 | 211,034 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 44.93 per share. | 31 Oct 2022 | 5,008 | 117,992 (0%) | 0% | 44.9 | 224,993 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 47.89 per share. | 31 Oct 2022 | 2,909 | 1,058,520 (2%) | 0% | 47.9 | 139,325 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 46.88 per share. | 31 Oct 2022 | 11,756 | 1,061,429 (2%) | 0% | 46.9 | 551,137 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 44.92 per share. | 31 Oct 2022 | 7,567 | 1,080,953 (2%) | 0% | 44.9 | 339,944 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 46.19 per share. | 31 Oct 2022 | 7,768 | 1,073,185 (2%) | 0% | 46.2 | 358,819 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 47.91 per share. | 31 Oct 2022 | 2,188 | 103,000 (0%) | 0% | 47.9 | 104,836 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 46.91 per share. | 31 Oct 2022 | 8,235 | 105,188 (0%) | 0% | 46.9 | 386,339 | Common Stock |
| Graham K. Cooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,391 | 10,391 | - | - | Stock Option (Right to Buy) | |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,391 | 10,391 | - | - | Stock Option (Right to Buy) | |
| Mark C. Fishman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,391 | 10,391 | - | - | Stock Option (Right to Buy) | |
| Kristina M. Burow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,391 | 10,391 | - | - | Stock Option (Right to Buy) | |
| Kathleen E. Walsh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,391 | 10,391 | - | - | Stock Option (Right to Buy) | |
| Carole Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,391 | 10,391 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 65.82 per share. | 28 Jul 2022 | 15,236 | 1,093,103 (2%) | 0% | 65.8 | 1,002,896 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 67.82 per share. | 28 Jul 2022 | 2,247 | 123,000 (0%) | 0% | 67.8 | 152,383 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 66.61 per share. | 28 Jul 2022 | 201 | 125,247 (0%) | 0% | 66.6 | 13,389 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 65.92 per share. | 28 Jul 2022 | 10,599 | 125,448 (0%) | 0% | 65.9 | 698,673 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 64.88 per share. | 28 Jul 2022 | 6,953 | 136,047 (0%) | 0% | 64.9 | 451,113 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 68.49 per share. | 28 Jul 2022 | 173 | 1,088,520 (2%) | 0% | 68.5 | 11,849 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 67.80 per share. | 28 Jul 2022 | 2,848 | 1,088,693 (2%) | 0% | 67.8 | 193,093 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 66.74 per share. | 28 Jul 2022 | 1,562 | 1,091,541 (2%) | 0% | 66.7 | 104,255 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 64.87 per share. | 28 Jul 2022 | 10,181 | 1,108,339 (2%) | 0% | 64.9 | 660,429 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 40.73 per share. | 28 Apr 2022 | 1,100 | 1,118,520 (2%) | 0% | 40.7 | 44,803 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 28 Apr 2022 | 12,246 | 1,101,316 (2%) | 0% | 7.2 | 88,416 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 28 Apr 2022 | 47,204 | 1,148,520 (2%) | 0% | 1.0 | 48,620 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 36.59 per share. | 28 Apr 2022 | 3,900 | 1,144,620 (2%) | 0% | 36.6 | 142,701 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 37.48 per share. | 28 Apr 2022 | 13,655 | 1,130,965 (2%) | 0% | 37.5 | 511,789 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 38.32 per share. | 28 Apr 2022 | 6,842 | 1,124,123 (2%) | 0% | 38.3 | 262,185 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 39.49 per share. | 28 Apr 2022 | 4,503 | 1,119,620 (2%) | 0% | 39.5 | 177,823 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 36.98 per share. | 28 Apr 2022 | 6,450 | 156,550 (0%) | 0% | 37.0 | 238,521 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 37.84 per share. | 28 Apr 2022 | 7,745 | 148,805 (0%) | 0% | 37.8 | 293,071 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 38.75 per share. | 28 Apr 2022 | 3,100 | 145,705 (0%) | 0% | 38.8 | 120,125 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 39.73 per share. | 28 Apr 2022 | 2,348 | 143,357 (0%) | 0% | 39.7 | 93,286 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 40.88 per share. | 28 Apr 2022 | 357 | 143,000 (0%) | 0% | 40.9 | 14,594 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2022 | 12,246 | 210,754 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2022 | 47,204 | 237,141 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 59.11 per share. | 31 Mar 2022 | 6,261 | 1,089,070 (2%) | 0% | 59.1 | 370,088 | Common Stock |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 56,250 | 1,095,331 (2%) | 0% | 0 | Common Stock | |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 59.11 per share. | 31 Mar 2022 | 1,859 | 115,614 (0%) | 0% | 59.1 | 109,885 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 15,000 | 117,473 (0%) | 0% | 0 | Common Stock | |
| Terry-Ann Burrell | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 15,000 | 40,065 (0%) | 0% | 0 | Common Stock | |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 59.11 per share. | 31 Mar 2022 | 1,787 | 38,278 (0%) | 0% | 59.1 | 105,630 | Common Stock |
| John Evans | Director, CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Jan 2022 | 12,000 | 968,825 (1%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 63.79 per share. | 31 Jan 2022 | 801 | 968,024 (1%) | 0% | 63.8 | 51,096 | Common Stock |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2022 | 112,500 | 112,500 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2022 | 100,000 | 284,345 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 68.16 per share. | 31 Jan 2022 | 2,672 | 163,000 (0%) | 0% | 68.2 | 182,124 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 67.43 per share. | 31 Jan 2022 | 9,408 | 165,672 (0%) | 0% | 67.4 | 634,381 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 66.48 per share. | 31 Jan 2022 | 4,105 | 175,080 (0%) | 0% | 66.5 | 272,900 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 65.55 per share. | 31 Jan 2022 | 1,900 | 179,185 (0%) | 0% | 65.6 | 124,545 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 64.46 per share. | 31 Jan 2022 | 1,615 | 181,085 (0%) | 0% | 64.5 | 104,103 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 63.45 per share. | 31 Jan 2022 | 300 | 182,700 (0%) | 0% | 63.5 | 19,035 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 31 Jan 2022 | 100,000 | 1,038,825 (2%) | 0% | 1.0 | 103,000 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 68.15 per share. | 31 Jan 2022 | 3,978 | 938,825 (1%) | 0% | 68.2 | 271,101 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 67.44 per share. | 31 Jan 2022 | 13,535 | 942,803 (1%) | 0% | 67.4 | 912,800 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 66.55 per share. | 31 Jan 2022 | 6,337 | 956,338 (1%) | 0% | 66.5 | 421,727 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 65.49 per share. | 31 Jan 2022 | 3,177 | 962,675 (1%) | 0% | 65.5 | 208,062 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 64.47 per share. | 31 Jan 2022 | 2,172 | 965,852 (1%) | 0% | 64.5 | 140,029 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2022 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2022 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2021 | 39,700 | 207,702 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 29 Dec 2021 | 39,700 | 102,473 (0%) | 0% | 0.7 | 26,599 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 87.34 per share. | 22 Dec 2021 | 290 | 62,773 (0%) | 0% | 87.3 | 25,329 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 86.62 per share. | 22 Dec 2021 | 1,101 | 63,063 (0%) | 0% | 86.6 | 95,369 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 85.39 per share. | 22 Dec 2021 | 1,216 | 64,164 (0%) | 0% | 85.4 | 103,834 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2021 | 2,607 | 89,646 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 22 Dec 2021 | 2,607 | 65,380 (0%) | 0% | 7.2 | 18,823 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 20 Dec 2021 | 4,289 | 67,062 (0%) | 0% | 7.2 | 30,967 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2021 | 25,104 | 92,253 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2021 | 4,289 | 117,357 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 86.29 per share. | 20 Dec 2021 | 8,648 | 62,773 (0%) | 0% | 86.3 | 746,236 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 85.38 per share. | 20 Dec 2021 | 16,456 | 71,421 (0%) | 0% | 85.4 | 1,405,013 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.22 per share. | 20 Dec 2021 | 25,104 | 87,877 (0%) | 0% | 7.2 | 181,251 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 85.20 per share. | 20 Dec 2021 | 4,289 | 62,773 (0%) | 0% | 85.2 | 365,423 | Common Stock |
| John M. Maraganore | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Nov 2021 | 13,133 | 13,133 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 82.72 per share. | 06 Oct 2021 | 3,149 | 1,058,076 (2%) | 0% | 82.7 | 260,485 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2021 | 27,700 | 331,645 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 85.24 per share. | 06 Oct 2021 | 400 | 183,000 (0%) | 0% | 85.2 | 34,096 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 84.45 per share. | 06 Oct 2021 | 7,566 | 183,400 (0%) | 0% | 84.5 | 638,949 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 83.49 per share. | 06 Oct 2021 | 9,863 | 190,966 (0%) | 0% | 83.5 | 823,462 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 82.71 per share. | 06 Oct 2021 | 2,171 | 200,829 (0%) | 0% | 82.7 | 179,563 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 85.19 per share. | 06 Oct 2021 | 701 | 1,033,525 (2%) | 0% | 85.2 | 59,718 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 84.45 per share. | 06 Oct 2021 | 10,444 | 1,034,226 (2%) | 0% | 84.5 | 881,996 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 83.47 per share. | 06 Oct 2021 | 13,406 | 1,044,670 (2%) | 0% | 83.5 | 1,118,999 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 06 Oct 2021 | 27,700 | 1,061,225 (2%) | 0% | 1.0 | 28,531 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2021 | 18,012 | 247,402 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 17 Sep 2021 | 18,012 | 62,773 (0%) | 0% | 0.7 | 12,068 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 97.50 per share. | 19 Aug 2021 | 1,000 | 221,600 (0%) | 0% | 97.5 | 97,500 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2021 | 12,000 | 359,345 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 19 Aug 2021 | 12,000 | 1,033,525 (2%) | 0% | 1.0 | 12,360 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 101.00 per share. | 19 Aug 2021 | 300 | 203,000 (0%) | 0% | 101 | 30,300 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 100.35 per share. | 19 Aug 2021 | 5,456 | 203,300 (0%) | 0% | 100.4 | 547,510 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 99.53 per share. | 19 Aug 2021 | 9,704 | 208,756 (0%) | 0% | 99.5 | 965,839 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 98.74 per share. | 19 Aug 2021 | 3,140 | 218,460 (0%) | 0% | 98.7 | 310,044 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 96.38 per share. | 19 Aug 2021 | 400 | 222,600 (0%) | 0% | 96.4 | 38,552 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 102.00 per share. | 07 Jul 2021 | 100 | 1,043,480 (2%) | 0% | 102 | 10,200 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2021 | 25,000 | 371,345 | - | - | Stock Option (Right to Buy | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 112.62 per share. | 07 Jul 2021 | 2,250 | 1,021,525 (2%) | 0% | 112.6 | 253,395 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 111.51 per share. | 07 Jul 2021 | 3,456 | 1,023,775 (2%) | 0% | 111.5 | 385,379 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 110.54 per share. | 07 Jul 2021 | 3,982 | 1,027,231 (2%) | 0% | 110.5 | 440,170 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 109.58 per share. | 07 Jul 2021 | 4,800 | 1,031,213 (2%) | 0% | 109.6 | 525,984 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 108.65 per share. | 07 Jul 2021 | 800 | 1,036,013 (2%) | 0% | 108.7 | 86,920 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 107.31 per share. | 07 Jul 2021 | 167 | 1,036,813 (2%) | 0% | 107.3 | 17,921 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 106.48 per share. | 07 Jul 2021 | 500 | 1,036,980 (2%) | 0% | 106.5 | 53,240 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 105.44 per share. | 07 Jul 2021 | 1,800 | 1,037,480 (2%) | 0% | 105.4 | 189,792 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 104.40 per share. | 07 Jul 2021 | 1,336 | 1,039,280 (2%) | 0% | 104.4 | 139,478 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 103.52 per share. | 07 Jul 2021 | 2,864 | 1,040,616 (2%) | 0% | 103.5 | 296,481 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 101.27 per share. | 07 Jul 2021 | 2,300 | 1,043,580 (2%) | 0% | 101.3 | 232,921 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 100.69 per share. | 07 Jul 2021 | 645 | 1,045,880 (2%) | 0% | 100.7 | 64,945 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 07 Jul 2021 | 25,000 | 1,046,525 (2%) | 0% | 1.0 | 25,750 | Common Stock |
| Graham K. Cooper | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.00 per share. | 06 Jul 2021 | 2,614 | 2,614 (0%) | 0% | 17 | 44,438 | Common Stock |
| Graham K. Cooper | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2021 | 2,614 | 16,561 | - | - | Stock Option (Right to Buy) | |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 129.38 per share. | 06 Jul 2021 | 100 | 0 (0%) | 0% | 129.4 | 12,938 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 128.67 per share. | 06 Jul 2021 | 100 | 100 (0%) | 0% | 128.7 | 12,867 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 126.51 per share. | 06 Jul 2021 | 100 | 200 (0%) | 0% | 126.5 | 12,651 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 124.31 per share. | 06 Jul 2021 | 300 | 300 (0%) | 0% | 124.3 | 37,293 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 123.76 per share. | 06 Jul 2021 | 200 | 600 (0%) | 0% | 123.8 | 24,752 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 122.85 per share. | 06 Jul 2021 | 100 | 800 (0%) | 0% | 122.9 | 12,285 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 121.59 per share. | 06 Jul 2021 | 400 | 900 (0%) | 0% | 121.6 | 48,636 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 120.39 per share. | 06 Jul 2021 | 200 | 1,300 (0%) | 0% | 120.4 | 24,078 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 119.68 per share. | 06 Jul 2021 | 100 | 1,500 (0%) | 0% | 119.7 | 11,968 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 118.35 per share. | 06 Jul 2021 | 200 | 1,600 (0%) | 0% | 118.4 | 23,670 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 116.41 per share. | 06 Jul 2021 | 200 | 1,800 (0%) | 0% | 116.4 | 23,282 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 115.38 per share. | 06 Jul 2021 | 614 | 2,000 (0%) | 0% | 115.4 | 70,843 | Common Stock |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 30 Jun 2021 | 200,000 | 2,921,519 (5%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 30 Jun 2021 | 2,011 | 12,067 (0%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 30 Jun 2021 | 200,000 | 2,921,520 (5%) | 0% | 0 | Common Stock | |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 117.00 per share. | 30 Jun 2021 | 15,000 | 39,809 (0%) | 0% | 117 | 1,755,000 | Common Stock |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 30 Jun 2021 | 30,000 | 54,809 (0%) | 0% | 13.7 | 410,400 | Common Stock |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2021 | 30,000 | 282,941 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 127.00 per share. | 30 Jun 2021 | 15,000 | 24,809 (0%) | 0% | 127 | 1,905,000 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 108.30 per share. | 28 Jun 2021 | 900 | 1,000 (0%) | 0% | 108.3 | 97,470 | Common Stock |
| Graham K. Cooper | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.00 per share. | 28 Jun 2021 | 12,045 | 12,045 (0%) | 0% | 17 | 204,765 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 105.37 per share. | 28 Jun 2021 | 5,787 | 6,258 (0%) | 0% | 105.4 | 609,776 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 106.28 per share. | 28 Jun 2021 | 3,196 | 3,062 (0%) | 0% | 106.3 | 339,671 | Common Stock |
| Graham K. Cooper | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2021 | 12,045 | 19,175 | - | - | Stock Option (Right to Buy) | |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 107.22 per share. | 28 Jun 2021 | 1,162 | 1,900 (0%) | 0% | 107.2 | 124,590 | Common Stock |
| Graham K. Cooper | Director | Sale of securities on an exchange or to another person at price $ 109.39 per share. | 28 Jun 2021 | 1,000 | 0 (0%) | 0% | 109.4 | 109,390 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 103.83 per share. | 28 Jun 2021 | 2,405 | 120,936 (0%) | 0% | 103.8 | 249,711 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.00 per share. | 28 Jun 2021 | 78,580 | 123,341 (0%) | 0% | 17 | 1,335,860 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 104.40 per share. | 28 Jun 2021 | 5,464 | 115,472 (0%) | 0% | 104.4 | 570,442 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 105.52 per share. | 28 Jun 2021 | 7,040 | 108,432 (0%) | 0% | 105.5 | 742,861 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 106.35 per share. | 28 Jun 2021 | 10,444 | 97,988 (0%) | 0% | 106.3 | 1,110,719 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 107.30 per share. | 28 Jun 2021 | 10,829 | 87,159 (0%) | 0% | 107.3 | 1,161,952 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 108.11 per share. | 28 Jun 2021 | 30,369 | 56,790 (0%) | 0% | 108.1 | 3,283,193 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 109.32 per share. | 28 Jun 2021 | 9,856 | 46,934 (0%) | 0% | 109.3 | 1,077,458 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Sale of securities on an exchange or to another person at price $ 110.00 per share. | 28 Jun 2021 | 2,173 | 44,761 (0%) | 0% | 110 | 239,030 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2021 | 78,580 | 432,313 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 106.13 per share. | 28 Jun 2021 | 8,907 | 52,702 (0%) | 0% | 106.1 | 945,300 | Common Stock |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 28 Jun 2021 | 45,000 | 69,809 (0%) | 0% | 13.7 | 615,600 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 103.86 per share. | 28 Jun 2021 | 1,100 | 68,709 (0%) | 0% | 103.9 | 114,246 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 104.63 per share. | 28 Jun 2021 | 1,880 | 66,829 (0%) | 0% | 104.6 | 196,704 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 105.34 per share. | 28 Jun 2021 | 5,220 | 61,609 (0%) | 0% | 105.3 | 549,875 | Common Stock |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2021 | 45,000 | 312,941 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 109.41 per share. | 28 Jun 2021 | 19,800 | 24,809 (0%) | 0% | 109.4 | 2,166,318 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 108.45 per share. | 28 Jun 2021 | 4,803 | 44,609 (0%) | 0% | 108.4 | 520,885 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 107.20 per share. | 28 Jun 2021 | 3,290 | 49,412 (0%) | 0% | 107.2 | 352,688 | Common Stock |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 200,000 | 3,321,519 (6%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 200,000 | 3,121,519 (6%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 200,000 | 3,121,520 (6%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 2,011 | 8,045 (0%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 200,000 | 3,321,520 (6%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 2,011 | 10,056 (0%) | 0% | 0 | Common Stock | |
| John Evans | Director, Chief Executive Officer | 25 Jun 2021 | 32 | 1,021,461 (2%) | 0% | 0 | Common Stock | ||
| John Evans | Director, Chief Executive Officer | 25 Jun 2021 | 32 | 1,021,493 (2%) | 0% | 0 | Common Stock | ||
| John Evans | Director, Chief Executive Officer | Other type of transaction at price $ 0.00 per share. | 25 Jun 2021 | 32 | 1,021,525 (2%) | 0% | 0 | Common Stock | |
| Graham K. Cooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 6,877 | 6,877 | - | - | Stock Option (Right to Buy) | |
| Mark C. Fishman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 6,877 | 6,877 | - | - | Stock Option (Right to Buy) | |
| Kristina Burow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 6,877 | 6,877 | - | - | Stock Option (Right to Buy) | |
| Kathleen E. Walsh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 3,126 | 3,126 | - | - | Stock Option (Right to Buy) | |
| Carole Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 6,877 | 6,877 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 71.79 per share. | 21 Apr 2021 | 2,994 | 1,015,429 (2%) | 0% | 71.8 | 214,939 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 71.38 per share. | 21 Apr 2021 | 9,869 | 1,018,423 (2%) | 0% | 71.4 | 704,449 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 70.23 per share. | 21 Apr 2021 | 5,595 | 1,028,292 (2%) | 0% | 70.2 | 392,937 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 67.90 per share. | 21 Apr 2021 | 1,463 | 1,038,966 (2%) | 0% | 67.9 | 99,338 | Common Stock |
| John Evans | Director, CEO | Sale of securities on an exchange or to another person at price $ 69.02 per share. | 21 Apr 2021 | 5,079 | 1,033,887 (2%) | 0% | 69.0 | 350,553 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2021 | 6,000 | 396,345 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 21 Apr 2021 | 6,000 | 1,021,429 (2%) | 0% | 1.0 | 6,180 | Common Stock |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 31 Mar 2021 | 200,000 | 3,521,519 (7%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 31 Mar 2021 | 4,686 | 14,053 (0%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 31 Mar 2021 | 200,000 | 3,521,520 (7%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 31 Mar 2021 | 200,000 | 3,521,520 (7%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 31 Mar 2021 | 2,011 | 6,034 (0%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 31 Mar 2021 | 200,000 | 3,521,519 (7%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 69,375 | 1,040,332 (2%) | 0% | 0 | Common Stock | |
| John Evans | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 138,750 | 138,750 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 17,500 | 24,809 (0%) | 0% | 0 | Common Stock | |
| Terry-Ann Burrell | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 4,684 | 9,367 (0%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 4,683 | 4,683 (0%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,921,519 (7%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,921,520 (7%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,721,520 (7%) | 0% | 0 | Common Stock | |
| Robert Taylor Nelsen | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,721,519 (7%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,921,520 (7%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 2,011 | 4,023 (0%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,721,519 (7%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,721,520 (7%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 2,012 | 2,012 (0%) | 0% | 0 | Common Stock | |
| Kristina Burow | Director | Other type of transaction at price $ 0.00 per share. | 18 Mar 2021 | 200,000 | 3,921,519 (7%) | 0% | 0 | Common Stock | |
| John Evans | Director, Chief Executive Officer | 18 Mar 2021 | 32 | 1,040,397 (2%) | 0% | 0 | Common Stock | ||
| John Evans | Director, Chief Executive Officer | 18 Mar 2021 | 32 | 1,040,429 (2%) | 0% | 0 | Common Stock | ||
| John Evans | Director, Chief Executive Officer | 18 Mar 2021 | 33 | 1,040,365 (2%) | 0% | 0 | Common Stock | ||
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 05 Mar 2021 | 4,030 | 19,761 (0%) | 0% | 0.7 | 2,700 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2021 | 25,000 | 44,761 (0%) | 0% | 0 | Common Stock | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2021 | 4,030 | 265,414 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2021 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Kathleen E. Walsh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2021 | 11,609 | 11,609 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 04 Jan 2021 | 25,000 | 32,309 (0%) | 0% | 13.7 | 342,000 | Common Stock |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2021 | 25,000 | 357,941 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 83.89 per share. | 04 Jan 2021 | 900 | 7,309 (0%) | 0% | 83.9 | 75,501 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 82.44 per share. | 04 Jan 2021 | 5,296 | 15,304 (0%) | 0% | 82.4 | 436,602 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 83.15 per share. | 04 Jan 2021 | 7,095 | 8,209 (0%) | 0% | 83.1 | 589,949 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 81.26 per share. | 04 Jan 2021 | 6,509 | 20,600 (0%) | 0% | 81.3 | 528,921 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 80.25 per share. | 04 Jan 2021 | 2,449 | 27,109 (0%) | 0% | 80.2 | 196,532 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 79.21 per share. | 04 Jan 2021 | 1,951 | 29,558 (0%) | 0% | 79.2 | 154,539 | Common Stock |
| Terry-Ann Burrell | CFO | Sale of securities on an exchange or to another person at price $ 78.05 per share. | 04 Jan 2021 | 800 | 31,509 (0%) | 0% | 78.1 | 62,440 | Common Stock |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2020 | 3,731 | 269,444 | - | - | Stock Option (Right to Buy) | |
| Giuseppe Ciaramella | President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.67 per share. | 30 Sep 2020 | 3,731 | 3,731 (0%) | 0% | 0.7 | 2,500 | Common Stock |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Sep 2020 | 7,309 | 382,941 | - | - | Stock Option (Right to Buy) | |
| Terry-Ann Burrell | CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.68 per share. | 18 Sep 2020 | 7,309 | 7,309 (0%) | 0% | 13.7 | 99,987 | Common Stock |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2020 | 115,000 | 402,345 | - | - | Stock Option (Right to Buy) | |
| John Evans | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.03 per share. | 16 Apr 2020 | 115,000 | 993,257 (1%) | 0% | 1.0 | 118,450 | Common Stock |
| Graham K. Cooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2020 | 31,220 | 31,220 | - | - | Stock Option (Right to Buy) | |
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 4,121,520 | 4,121,520 (8%) | 8% | - | Common Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 4,121,519 | 4,121,519 (8%) | 8% | - | Common Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 1,338,000 | 0 | - | - | Series A-1 Preferred Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 1,338,000 | 0 | - | - | Series A-1 Preferred Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 2,750,336 | 0 | - | - | Series A-2 Preferred Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 2,750,335 | 0 | - | - | Series A-2 Preferred Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 33,184 | 0 | - | - | Series B Preferred Stock | ||
| Robert T. Nelsen | Director, Ten Percent Owner | 10 Feb 2020 | 33,184 | 0 | - | - | Series B Preferred Stock | ||
| Mark C. Fishman | Director | 10 Feb 2020 | 1,239 | 0 | - | - | Series A-2 Preferred Stock | ||
| Mark C. Fishman | Director | 10 Feb 2020 | 17,007 | 17,007 (0%) | 0% | - | Common Stock | ||
| Mark C. Fishman | Director | 10 Feb 2020 | 15,768 | 0 | - | - | Series A-1 Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 4,121,520 | 4,121,520 (8%) | 8% | - | Common Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 33,184 | 0 | - | - | Series B Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 33,184 | 0 | - | - | Series B Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 2,750,335 | 0 | - | - | Series A-2 Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 2,750,336 | 0 | - | - | Series A-2 Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 1,338,000 | 0 | - | - | Series A-1 Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 1,338,000 | 0 | - | - | Series A-1 Preferred Stock | ||
| Kristina Burow | Director | 10 Feb 2020 | 4,121,519 | 4,121,519 (8%) | 8% | - | Common Stock | ||
| Giuseppe Ciaramella | President & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2020 | 510,893 | 510,893 | - | - | Stock Option (Right to Buy) |